| Name | Revenue | Assets | Income | Top executive | |
| 1 | Roseman University of Health Sciences 11 Sunset Way, Henderson, NV 89014 | $109,525,635 | $156,259,391 | $111,800,963 | Renee Coffman, president and co-founder |
| 2 | Three Square 4190 N. Pecos Road, Las Vegas, NV 89115 | $61,184,127 | $30,694,093 | $61,653,434 | Brian Burton, president and CEO |
| 3 | Home Means Nevada Inc. 2250 Las Vegas Blvd. North, Suite 600, North Las Vegas, NV 89030 | $49,003,261 | $99,639,784 | $49,003,261 | CJ Manthe, president |
| 4 | University of Nevada School of Medicine 1701 W. Charleston Blvd., Las Vegas, NV 89102 | $32,851,388 | $13,512,896 | $32,851,388 | Thomas Schwenk, dean |
| 5 | Goodwill Industries of Southern Nevada Inc. 1280 W. Cheyenne Ave., North Las Vegas, NV 89030 | $32,185,513 | $9,911,147 | $32,506,316 | Steve Chartrand, president and CEO |
| 6 | The Smith Center for the Performing Arts 361 Symphony Park Ave., Las Vegas, NV 89106 | $30,728,610 | $445,404,620 | $81,437,046 | Myron Martin, president and CEO |
| 7 | Nathan Adelson Hospice Inc. 4141 Swenson St., Las Vegas, NV 89119 | $28,653,204 | $21,389,674 | $28,653,204 | Carole Fisher, president and CEO |
| 8 | Opportunity Village 6050 S. Buffalo Drive, Las Vegas, NV 89113 | $27,210,961 | $37,592,844 | $29,099,803 | Robert Brown, president |
| 9 | University of Nevada School of Medicine Multi-Speciality Group Practice 2040 W. Charleston Blvd., Suite 400, Las Vegas, NV 89102 | $24,916,807 | $0 | $24,916,807 | Thomas Schwenk, dean |
| 10 | Boulder City Hospital Inc. 901 Adams Blvd., Boulder City, NV 89005 | $21,912,196 | $26,005,451 | $21,942,598 | Tom Maher, CEO |
| 11 | United Way of Southern Nevada Inc. 5830 W. Flamingo Road, Las Vegas, NV 89103 | $21,103,607 | $9,001,110 | $21,118,930 | Bob Morgan, president and CEO |
| 12 | Nevada Family Practice Residency 4000 E. Charleston Blvd., Suite 230, Las Vegas, NV 89104 | $20,741,443 | $15,249,000 | $20,741,443 | Did not disclose |
| 13 | Alliance for Childhood Diseases 3121 S. Maryland Parkway, Suite 601, Las Vegas, NV 89109 | $20,530,835 | $17,536,078 | $20,530,835 | Annette Logan, executive director |
| 14 | Meadows School 8601 Scholar Lane, Las Vegas, NV 89128 | $20,443,433 | $61,741,273 | $31,254,751 | Jeremy Gregersen, head of school |
| 15 | Catholic Charities of Southern Nevada 1501 Las Vegas Blvd. North, Las Vegas, NV 89101 | $20,082,720 | $21,379,477 | $22,276,400 | Joseph Pepe, chairman |
| 16 | Nevada Donor Network Inc. 2061 E. Sahara Ave., Las Vegas, NV 89104 | $19,415,064 | $12,818,213 | $19,415,064 | Joseph Ferreira, CEO |
| 17 | Las Vegas-Clark County Urban League 3575 W. Cheyenne Ave., North Las Vegas, NV 89032 | $16,706,041 | $2,988,305 | $16,752,873 | Kevin Hooks, CEO |
| 18 | Western Veterinary Conference 2425 E. Oquendo Road, Las Vegas, NV 89120 | $14,426,071 | $18,736,863 | $14,426,071 | Dr. Randall Ezell, president |
Source: Internal Revenue Service and VEGAS INC research. It is not the intent of this list to endorse the participants or to imply that the listing of a company indicates its quality. Although every attempt is made to ensure the accuracy and thoroughness of VEGAS INC charts, omissions sometimes occur and some businesses do not respond. Please send corrections or additions on company letterhead to Julie Ann Formoso, research associate, VEGAS INC, 2360 Corporate Circle, Third Floor, Henderson, NV 89074.